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Occurrence of Plasmid-Mediated Quinolone Resistance and Carbapenemase-Encoding Genes in Pseudomonas aeruginosa Isolates from Nosocomial Patients in Aguascalientes, Mexico
| dc.contributor.author | Tapia Cornejo, Ana S. | |
| dc.contributor.author | Ramírez Castillo, Flor Y. | |
| dc.contributor.author | Guerrero Barrera, Alma L. | |
| dc.contributor.author | Guillen Padilla, Diana E. | |
| dc.contributor.author | Arreola Guerra, José M. | |
| dc.contributor.author | González Gámez, Mario | |
| dc.contributor.author | Avelar González, Francisco J. | |
| dc.contributor.author | Loera Muro, Abraham | |
| dc.contributor.author | Hernández Cuellar, Eduardo | |
| dc.contributor.author | Ramos Medellín, Carmen L. | |
| dc.contributor.author | Adame Álvarez, Cesar | |
| dc.contributor.author | García Romo, Ricardo | |
| dc.contributor.author | Galindo Guerrero, Fabiola | |
| dc.contributor.author | Moreno Flores, Adriana C. | |
| dc.date.issued | 2024 | |
| dc.identifier | https://cibnor.repositorioinstitucional.mx/jspui/handle/1001/3172 | |
| dc.identifier.other | doi.org/10.3390/pathogens13110992 | |
| dc.identifier.uri | http://dspace.cibnor.mx:8080/handle/123456789/3391 | |
| dc.format | es | |
| dc.language.iso | eng | es |
| dc.publisher | MDPI | es |
| dc.rights | Acceso abierto | es |
| dc.subject | carbapenemase-encoding genes, Plasmid-Mediated Quinolone Resistance (PMQR) genes, mcr-1, Pseudomonas aeruginosa, multidrug-resistance | es |
| dc.subject.classification | BACTERIOLOGÍA | es |
| dc.title | Occurrence of Plasmid-Mediated Quinolone Resistance and Carbapenemase-Encoding Genes in Pseudomonas aeruginosa Isolates from Nosocomial Patients in Aguascalientes, Mexico | es |
| dc.type | article | es |
| dc.description.abstracten | "Pseudomonas aeruginosa is a leading cause of healthcare-associated infections, which are related to substantial morbidity and mortality. The incidence of Plasmid-Mediated Quinolone Resistance (PMQR)determinants has been previously reported in this bacterium. However, there is limited information regarding the presence of PMQR and carbapenemase-encoding genes simultaneously. This study aims to analyze the prevalence of these determinants on P. aeruginosa strain isolated from clinical patients in the State of Aguascalientes, Mexico. Fifty-two P. aeruginosa isolates from nosocomial patients were collected from Centenario Hospital Miguel Hidalgo. This is a retrospective observational study conducted at a single center. Antibiotic susceptibility was tested using the Vitek-2 system. Only carbapenem-resistant isolates were included in this study. Carbapenemase-encoding genes and PMQRdeterminants were screened by polymerase chain reaction (PCR). Resistance rates of 100% were found on tigecycline and ceftriaxone. Of the 52 isolates, 34.6% were positive for the qnr genes, 46.2% for the oqxA gene, and 25% for the aac-(6′)-lb gene. The most frequent carbapenemase genes found in the samples were blaOXA-51 (42.3%), blaOXA-1 (15.4%), and blaVIM (15.4%). blaOXA-51 co-carrying oqxA was detected in 21.1% of the isolates, blaOXA-51 co-carrying aac-(6’)-lb in 11.5%, blaVIM co-carrying aac-(6′)-lb in 3.8%, and blaKPC co-carrying oqxA in 5.8%. Systematic surveillance to detect carbapenemase-encoding genes and PMQR determinants, and rational prescription using the last-line drugs could help in preventing the dissemination of multidrug-resistant determinants." | es |
