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Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target

dc.creatorLILIANA CAROLINA ROJO ARREOLA
dc.date2017
dc.identifierhttp://cibnor.repositorioinstitucional.mx/jspui/handle/1001/952
dc.identifier.urihttp://dspace.cibnor.mx:8080/handle/123456789/1906
dc.description"Reliance on just one drug to treat the prevalent tropical disease, schistosomiasis, spurs the search for new drugs and drug targets. Inhibitors of human cyclic nucleotide phosphodiesterases (huPDEs), including PDE4, are under development as novel drugs to treat a range of chronic indications including asthma, chronic obstructive pulmonary disease and Alzheimer's disease. One class of huPDE4 inhibitors that has yielded marketed drugs is the benzoxaboroles (Anacor Pharmaceuticals)."
dc.formatapplication/pdf
dc.languageeng
dc.publisherMcGill University
dc.relationinfo:eu-repo/semantics/reference/DOI/doi.org/10.1371/journal.pntd.0005680
dc.relationinfo:eu-repo/semantics/reference/URL/URL: http://journals.plos.org/plosntds/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourcePLOS Neglected Tropical Diseases
dc.subjectinfo:eu-repo/classification/AUTOR/flatworm disease, tropical disease
dc.subjectinfo:eu-repo/classification/cti/3
dc.subjectinfo:eu-repo/classification/cti/32
dc.subjectinfo:eu-repo/classification/cti/3207
dc.subjectinfo:eu-repo/classification/cti/320712
dc.subjectinfo:eu-repo/classification/cti/320712
dc.titlePhenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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