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Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors

dc.creatorMARIO ALBERTO BURGOS ACEVES
dc.creatorTamar Kahan
dc.date2017
dc.identifierhttp://cibnor.repositorioinstitucional.mx/jspui/handle/1001/1072
dc.identifier.urihttp://dspace.cibnor.mx:8080/handle/123456789/1820
dc.description"Widespread microRNA (miRNA) repression is a phenomenon observed in mammals after exposure to cigarette smoke and in many types of cancer. A comprehensive reduction in miRNA expression after treatment with the hormone estrogen has also previously been described. Here, we reveal a conserved association of miRNA downregulation after estrogen exposure in zebrafish, mouse, and human breast cancer cell line, with a high guanine content in the terminal loop sequences of their precursors, and offer a possible link between estrogen-related miRNA-adducts formation and carcinogenesis. We also show common gene expression patterns shared by breast cancer tumors and estrogen-treated zebrafish, suggesting that this organism can be used as a powerful model system for the study of human breast cancer."
dc.formatapplication/pdf
dc.languageeng
dc.publisherMultidisciplinary Digital Publishing Institute
dc.relationinfo:eu-repo/semantics/reference/DOI/DOI: 10.3390/biomedicines5030047
dc.relationinfo:eu-repo/semantics/reference/ISSN/ISSN: 2227-9059
dc.relationinfo:eu-repo/semantics/reference/URL/URL: http://www.mdpi.com/journal/biomedicines
dc.relationcitation:Cohen, A.; Burgos-Aceves, M.A.; Kahan, T.; Smith, Y. Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors. Biomedicines 2017, 5, 47.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceBiomedicines
dc.subjectinfo:eu-repo/classification/AUTOR/estrogen, microRNA, Terminal loop, Guanine, cigarette smoke, xenoestrogens, DNA adducts, cancer
dc.subjectinfo:eu-repo/classification/cti/3
dc.subjectinfo:eu-repo/classification/cti/32
dc.subjectinfo:eu-repo/classification/cti/3207
dc.subjectinfo:eu-repo/classification/cti/320713
dc.subjectinfo:eu-repo/classification/cti/320713
dc.titleEstrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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