dc.creator | MARIO ALBERTO BURGOS ACEVES | |
dc.creator | Tamar Kahan | |
dc.date | 2017 | |
dc.identifier | http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/1072 | |
dc.identifier.uri | http://dspace.cibnor.mx:8080/handle/123456789/1820 | |
dc.description | "Widespread microRNA (miRNA) repression is a phenomenon observed in mammals after exposure to cigarette smoke and in many types of cancer. A comprehensive reduction in miRNA expression after treatment with the hormone estrogen has also previously been described. Here, we reveal a conserved association of miRNA downregulation after estrogen exposure in zebrafish, mouse, and human breast cancer cell line, with a high guanine content in the terminal loop sequences of their precursors, and offer a possible link between estrogen-related miRNA-adducts formation and carcinogenesis. We also show common gene expression patterns shared by breast cancer tumors and estrogen-treated zebrafish, suggesting that this organism can be used as a powerful model system for the study of human breast cancer." | |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | Multidisciplinary Digital Publishing Institute | |
dc.relation | info:eu-repo/semantics/reference/DOI/DOI: 10.3390/biomedicines5030047 | |
dc.relation | info:eu-repo/semantics/reference/ISSN/ISSN: 2227-9059 | |
dc.relation | info:eu-repo/semantics/reference/URL/URL: http://www.mdpi.com/journal/biomedicines | |
dc.relation | citation:Cohen, A.; Burgos-Aceves, M.A.; Kahan, T.; Smith, Y. Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors. Biomedicines 2017, 5, 47. | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.source | Biomedicines | |
dc.subject | info:eu-repo/classification/AUTOR/estrogen, microRNA, Terminal loop, Guanine, cigarette smoke, xenoestrogens, DNA adducts, cancer | |
dc.subject | info:eu-repo/classification/cti/3 | |
dc.subject | info:eu-repo/classification/cti/32 | |
dc.subject | info:eu-repo/classification/cti/3207 | |
dc.subject | info:eu-repo/classification/cti/320713 | |
dc.subject | info:eu-repo/classification/cti/320713 | |
dc.title | Estrogen Repression of MicroRNAs Is Associated with High Guanine Content in the Terminal Loop Sequences of Their Precursors | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |