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A Perspective on the Development of Plant-Made vaccines in the Fight against ebola virus

dc.creatorSERGIO ROSALES MENDOZA
dc.creatorRICARDO NIETO GOMEZ
dc.creatorCARLOS ELIUD ANGULO VALADEZ
dc.date2017
dc.identifierhttp://cibnor.repositorioinstitucional.mx/jspui/handle/1001/764
dc.identifier.urihttp://dspace.cibnor.mx:8080/handle/123456789/1489
dc.description"The Ebola virus (EBOV) epidemic indicated a great need for prophylactic and therapeutic strategies. The use of plants for the production of biopharmaceuticals is a concept being adopted by the pharmaceutical industry, with an enzyme for human use currently commercialized since 2012 and some plant-based vaccines close to being commercialized. Although plant-based antibodies against EBOV are under clinical evaluation, the development of plant-based vaccines against EBOV essentially remains an unexplored area. The current technologies for the production of plant-based vaccines include stable nuclear expression, transient expression mediated by viral vectors, and chloroplast expression. Specific perspectives on how these technologies can be applied for developing anti- EBOV vaccines are provided, including possibilities for the design of immunogens as well as the potential of the distinct expression modalities to produce the most relevant EBOV antigens in plants considering yields, posttranslational modifications, production time, and downstream processing."
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media, S. A.
dc.relationinfo:eu-repo/semantics/reference/ISSN/ISSN: 1664-3224
dc.relationinfo:eu-repo/semantics/reference/URL/URL: https://www.frontiersin.org/journals/immunology
dc.relationinfo:eu-repo/semantics/reference/DOI/DOI: 10.3389/fimmu.2017.00252
dc.relationcitation:Rosales-Mendoza S, Nieto-Gómez R and Angulo C (2017) A Perspective on the Development of Plant-Made Vaccines in the Fight against Ebola Virus. Front. Immunol. 8:252
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceFrontiers in Immunology
dc.subjectinfo:eu-repo/classification/AUTOR/Ebola virus, mucosal immunization, low-cost vaccine, global vaccination, molecular pharming, glycoprotein antigen, VP antigen
dc.subjectinfo:eu-repo/classification/cti/2
dc.subjectinfo:eu-repo/classification/cti/24
dc.subjectinfo:eu-repo/classification/cti/2412
dc.subjectinfo:eu-repo/classification/cti/241210
dc.titleA Perspective on the Development of Plant-Made vaccines in the Fight against ebola virus
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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