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The Neuroprotective Effect of Erythropoietin in Rat Hippocampus in an Endotoxic Shock Model

dc.creatorLUIS JAVIER RAMIREZ JIRANO
dc.creatorTANIA ZENTENO SAVIN
dc.creatorRAMON GAXIOLA ROBLES
dc.creatorELSY JANETH RAMOS GONZALEZ
dc.creatorBLANCA MIRIAM DE GUADALUPE TORRES MENDOZA
dc.creatorOSCAR KURT BITZER QUINTERO
dc.date2016
dc.identifierhttp://cibnor.repositorioinstitucional.mx/jspui/handle/1001/761
dc.identifier.urihttp://dspace.cibnor.mx:8080/handle/123456789/1486
dc.description"Sepsis is characterized by an early systemic inflammation in response to infection. In the brain, inflammation is associated with expression of pro-inflammatory cytokines (e.g. tumor necrosis factor-α, interleukin-1β and interleukin-6, among others) that may induce an overproduction of reactive oxygen and nitrogen species. The constitutive expression of cytokines in the brain is low, but may be induced by various stimuli, including lipopolysaccharide, which causes neuronal damage. Erythropoietin, among other effects, acts as a multifunctional neurotrophic factor implicated in neurogenesis, angiogenesis, vascular permeability, and immune regulation in the central nervous system. In an experimental model of endotoxic shock, we studied the neuroprotective capacity of erythropoietin in the rat hippocampus and compared with melatonin, a neurohormone with an important antioxidant and immunomodulatory effect. Methods: In 21-day-old male Wistar rats divided into eight groups, we administered by intraperitoneal injection lipopolysaccharide, erythropoietin, melatonin, or combinations thereof. The hippocampus was dissected and morphological (histological analysis) and biochemical (cytokine levels) studies were conducted. Results: The number of dead neuronal cells in histological sections in groups treated with lipopolysaccharide was higher compared to the erythropoietin group. There was a greater decrease (70%) in interleukin-1β concentrations in rats with endotoxic shock that received erythropoietin compared to the lipopolysaccharide group."
dc.formatapplication/pdf
dc.languageeng
dc.publisherInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
dc.relationinfo:eu-repo/semantics/reference/ISSN/ISSN: 2564-8896
dc.relationinfo:eu-repo/semantics/reference/URL/URL: http://clinicalandtranslationalinvestigation.com
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceREVISTA DE INVESTIGACIÓN CLÍNICA
dc.subjectinfo:eu-repo/classification/AUTOR/Erythropoietin, Endotoxic shock, Neuroimmunology, Neuroinflammation, Oxidative stress
dc.subjectinfo:eu-repo/classification/cti/3
dc.subjectinfo:eu-repo/classification/cti/32
dc.subjectinfo:eu-repo/classification/cti/3207
dc.subjectinfo:eu-repo/classification/cti/320711
dc.titleThe Neuroprotective Effect of Erythropoietin in Rat Hippocampus in an Endotoxic Shock Model
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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