Inicio | CIBNOR | CONACYT
    • español
    • English
  • English 
    • español
    • English
  • Login
View Item 
  •   DSpace Home
  • Recursos Digitales
  • Artículos
  • View Item
  •   DSpace Home
  • Recursos Digitales
  • Artículos
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.
FacebookTwitterYoutube

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

The Neuroprotective Effect of Erythropoietin in Rat Hippocampus in an Endotoxic Shock Model

Thumbnail
Author
LUIS JAVIER RAMIREZ JIRANO
TANIA ZENTENO SAVIN
RAMON GAXIOLA ROBLES
ELSY JANETH RAMOS GONZALEZ
BLANCA MIRIAM DE GUADALUPE TORRES MENDOZA
OSCAR KURT BITZER QUINTERO
Metadata
Show full item record
Abstract
"Sepsis is characterized by an early systemic inflammation in response to infection. In the brain, inflammation is associated with expression of pro-inflammatory cytokines (e.g. tumor necrosis factor-α, interleukin-1β and interleukin-6, among others) that may induce an overproduction of reactive oxygen and nitrogen species. The constitutive expression of cytokines in the brain is low, but may be induced by various stimuli, including lipopolysaccharide, which causes neuronal damage. Erythropoietin, among other effects, acts as a multifunctional neurotrophic factor implicated in neurogenesis, angiogenesis, vascular permeability, and immune regulation in the central nervous system. In an experimental model of endotoxic shock, we studied the neuroprotective capacity of erythropoietin in the rat hippocampus and compared with melatonin, a neurohormone with an important antioxidant and immunomodulatory effect. Methods: In 21-day-old male Wistar rats divided into eight groups, we administered by intraperitoneal injection lipopolysaccharide, erythropoietin, melatonin, or combinations thereof. The hippocampus was dissected and morphological (histological analysis) and biochemical (cytokine levels) studies were conducted. Results: The number of dead neuronal cells in histological sections in groups treated with lipopolysaccharide was higher compared to the erythropoietin group. There was a greater decrease (70%) in interleukin-1β concentrations in rats with endotoxic shock that received erythropoietin compared to the lipopolysaccharide group."
URI Nacional
http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/761
URI
http://dspace.cibnor.mx:8080/handle/123456789/1486
Collections
  • Artículos

Related items

Showing items related by title, author, creator and subject.

  • Thumbnail

    PROMOCIÓN DEL PERIFITON PARA EL CULTIVO DE CAMARÓN BLANCO: HACIA UNA ACUICULTURA ECOLÓGICA 

    DOMENICO VOLTOLINA LOBINA; JUAN MANUEL AUDELO NARANJO; MARIA DEL ROSARIO PACHECO MARGES
  • Thumbnail

    Identificación y cuantificación de ciguatoxinas en peces carnívoros de la península de Yucatán 

    TAI COH LEY MARTINEZ
  • Thumbnail

    Suelo y Erosión 

    YOLANDA LOURDES MAYA DELGADO

Contact Us | Send Feedback

Centro de Investigaciones Biológicas del Noroeste, s.c.
Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur La Paz, B.C.S. México
C.P. 23096, Tel:(52) (612) 123-8484 Fax:(52) (612) 125-3625