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Oxidative Stress in Patients with Rheumatoid Arthritis

dc.creatorADOLFO GARCIA GONZALEZ
dc.creatorRAMON GAXIOLA ROBLES
dc.creatorTANIA ZENTENO SAVIN
dc.date2015
dc.identifierhttp://cibnor.repositorioinstitucional.mx/jspui/handle/1001/759
dc.identifier.urihttp://dspace.cibnor.mx:8080/handle/123456789/1484
dc.description"Rheumatoid arthritis is an autoimmune disease of unknown etiology, characterized by articular inflammation. Oxidative damage induced by reactive oxygen species has been related to the pathophysiology of rheumatoid arthritis in several studies, although results have been inconsistent and contradictory. Objective: To determine oxidative stress markers in patients with rheumatoid arthritis. Methods: Descriptive cross-sectional study in rheumatoid arthritis patients and healthy controls. In peripheral blood samples from all study subjects, lipid peroxide (thiobarbituric acid reactive substances) and protein carbonyl levels were quantified as oxidative damage markers; superoxide dismutase and glutathione peroxidase activities, glutathione concentration, and the reduced glutathione/oxidized glutathione ratio were analyzed as antioxidant defense indicators. Mann- Whitney U tests were run. Statistical significance (a) was 0.05%. Results: We included 29 rheumatoid arthritis patients, 10 with active disease, and 41 healthy controls. Age was higher in the rheumatoid arthritis group; there were no differences in female:male ratio between groups. Oxidative damage was higher in rheumatoid arthritis patients; however, there was no difference between patients with active or inactive rheumatoid arthritis. Antioxidant enzyme activities, glutathione concentration, and reduced glutathione/oxidized glutathione ratio were higher in rheumatoid arthritis patients than in controls."
dc.formatapplication/pdf
dc.languageeng
dc.publisherInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
dc.relationinfo:eu-repo/semantics/reference/ISSN/ISSN: 2564-8896
dc.relationinfo:eu-repo/semantics/reference/URL/URL: http://clinicalandtranslationalinvestigation.com
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceREVISTA DE INVESTIGACIÓN CLÍNICA
dc.subjectinfo:eu-repo/classification/AUTOR/Antioxidant enzymes, Glutathione, Oxidative stress, Rheumatoid arthritis
dc.subjectinfo:eu-repo/classification/cti/3
dc.subjectinfo:eu-repo/classification/cti/32
dc.subjectinfo:eu-repo/classification/cti/2410
dc.subjectinfo:eu-repo/classification/cti/230208
dc.titleOxidative Stress in Patients with Rheumatoid Arthritis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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